Yet again, the cycle continues, after the latest patch I'm experiencing frame drops, especially in Chaos missions.

Is this an issue anyone else is experiencing, or is it an isolated case?

I have r7 5700x3d and rx 6800xt

I've been experiencing this as well, happens in tyranid missions too, especially in the last part of Termination. The game used to run great(with the exception of stuttering during the explosion at the bridge in Decapitation) at max settings before the patch, now it has fps drops and stutters. I've reduced the settings to High and even reduced the effects to medium I think, it's faring a tad bit better now but still having a bad performance. I've filed a bug report and I saw other people reporting it as well. I hope they prioritize this.